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calendar_month Aug 21, 2026

Tempus AI Stock Climbs Friday: What’s Driving the Move?

Tempus AI Inc. (NASDAQ:TEM) shares are trading higher on Friday as traders continue to digest the latest follow-through from this week’s Merck–Moderna clinical-trial headline.

What Sparked Tempus AI’s Recent Price Action?

The recent spark for TEM was Phase 3 INTerpath-001 results from Merck & Co. and Moderna Inc., where intismeran autogene (a custom mRNA neoantigen therapy) paired with Keytruda improved recurrence-free survival in resected melanoma, described as the first successful Phase 3 readout for a custom mRNA-based cancer treatment.

The personalized vaccine relies on Personalis Inc.’s genomic tumor-profiling technology, which Moderna uses to analyze patient tissue and identify specific neoantigens for custom doses.

This link directly benefits Tempus AI, which agreed to acquire Personalis for $1.5 billion last month after previously partnering with the firm on minimal residual disease tests. The acquisition hands Tempus the vital sequencing infrastructure supporting Moderna’s therapeutic program right as it achieves its major Phase 3 clinical milestone.

Tempus CEO Eric Lefkofsky highlighted the connection on social media Wednesday, congratulating Moderna and Merck while noting Tempus’s pride in supporting the breakthrough program.

Critical Levels To Watch For TEM Stock

TEM is extended versus its trend gauges, trading about 33% above its 20-day SMA ($51.08) and about 19.7% above its 200-day SMA ($56.75), which often raises the odds of a pause or pullback even if the bigger move stays intact. That stretch is happening while the longer-term backdrop still carries baggage from the death cross in January (50-day SMA below the 200-day SMA), a reminder that the stock can stay volatile when momentum cools.

RSI is the cleaner momentum lens right now: at 71.53, it’s in overbought territory, which typically signals the move is getting “stretched” and can mean upside becomes harder to sustain without a reset. The key question for trend traders is whether any dip is shallow (bullish consolidation) or whether it starts closing the gap back toward the major moving averages.

  • Key Resistance: $76.50 — a nearby pivot area where rebounds can stall after a fast run
  • Key Support: $61.50 — a recent floor area that sits relatively close to current price and can define whether the pullback stays controlled

TEM Stock Price Activity on Friday

TEM Price Action: Tempus AI shares were up 5.09% at $70.04 at the time of publication on Friday, according to Benzinga Pro data.

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